A study reveals how chromosomal instability and resultant TP53 loss enhance fatty acid metabolism to drive breast cancer brain metastasis. This metabolic dependency provides new insights into therapeutic vulnerabilities of aneuploid tumors.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$32.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Ben-David, U. & Amon, A. Nat. Rev. Genet. 21, 44–62 (2020).
Bakhoum, S. F. & Cantley, L. C. Cell 174, 1347–1360 (2018).
Laue, K. et al. Nat. Genet. https://doi.org/10.1038/s41588-025-02446-1 (2025).
Burrell, R. A., McGranahan, N., Bartek, J. & Swanton, C. Nature 501, 338–345 (2013).
Nguyen, B. et al. Cell 185, 563–575.e11 (2022).
Min, J.-Y. & Kim, D.-H. Int. J. Mol. Sci. 24, 8951 (2023).
Che, G. et al. Clin. Transl. Med. 14, e1587 (2024).
Schwab, A. et al. Nat. Cell Biol. 26, 1470–1481 (2024).
Kelly, W. et al. Clin. Cancer Res. 29, 2419–2425 (2023).
Nuber, S. et al. Neurotherapeutics 19, 1018–1036 (2022).
Katoh, Y. et al. J. Immunother. Cancer 10, e004616 (2022).
Tzeng, S.-F. et al. Cancer Discov. 15, 1676–1696 (2025).
Davoli, T., Uno, H., Wooten, E. C. & Elledge, S. J. Science 355, eaaf8399 (2017).
Al-Rawi, D. H., Lettera, E., Li, J., DiBona, M. & Bakhoum, S. F. Nat. Rev. Clin. Oncol. 21, 645–659 (2024).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
S.F.B. is a co-founder, chief scientific officer and a member of the board of directors at Volastra Therapeutics Inc., where he owns equity and from which he receives compensation. He also serves on the scientific advisory board of Meliora Therapeutics and Arinale Biosciences Inc. The work presented herein is unrelated to these affiliations, and these entities had no role in the conception, conduct or reporting of this research.
Rights and permissions
About this article
Cite this article
Bakhoum, S.F. Aneuploidy-driven vulnerabilities in breast cancer metastasis. Nat Genet 58, 14–15 (2026). https://doi.org/10.1038/s41588-025-02444-3
Published:
Version of record:
Issue date:
DOI: https://doi.org/10.1038/s41588-025-02444-3
