Fig. 5: Genome architecture retains partial memory of the past conformation.
a, Saddle plots of compartment interactions in cis (top) and in trans (bottom) in DMSO, TSA and REC Micro-C. b, High-resolution eigenvector tracks of the Micro-C data showing small-scale compartment switch around the F11–Klkb1–Cyp4v3 that persists in recovery. Gene expression z score is shown on the right. c, Micro-C maps at the Pitx2 locus showing incomplete architectural recovery. Normalized ChIP–seq tracks of the corresponding condition are shown above. d, Pile-up of Micro-C signal around differential loops in DMSO, TSA and recovery (resolution = 4 kb). Quantification of piled-up loop signal (n = 9 corresponding to the central 3 × 3 pixels) is shown on the right (paired two-tailed t test; NS > 0.05, **P < 0.01). Data shown are the median, with hinges corresponding to IQR and whiskers extending to the lowest and highest values within 1.5× IQR.
