Extended Data Fig. 9: Normalizing skull haematopoiesis promotes clonal expansion and tumour infiltration of effector T cells. | Nature Genetics

Extended Data Fig. 9: Normalizing skull haematopoiesis promotes clonal expansion and tumour infiltration of effector T cells.

From: Childhood brain tumors instruct cranial hematopoiesis and immunotolerance

Extended Data Fig. 9

a, Uniform-manifold projection of intratumoural T cells in endpoint vehicle and mavrilimumab-treated EPZFTA-RELA-bearing mice, coloured by phenotype and quantified in b. c, UMAP of clone size of intratumoural T cells in mavrilimumab-treated mice. d, Gene Ontology (GO) pathway analysis top differentially upregulated genes in expanded intratumoural T cell clones (>3) relative to non-expanded clones. e, dotplot of top 20 differentially upregulated genes across T cell phenotype clusters in mavrilimumab-treated mice, n = 2 pooled experiments per group.

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