Extended Data Fig. 7: Regional association plots of variants in the FUT2, MUC12, CORO7–HMOX2, FOXP1, and SLC5A11 gene loci. | Nature Genetics

Extended Data Fig. 7: Regional association plots of variants in the FUT2, MUC12, CORO7–HMOX2, FOXP1, and SLC5A11 gene loci.

From: Genome-wide association analyses highlight the role of the intestinal molecular environment in human gut microbiota variation

Extended Data Fig. 7

a-h, Regional association plots of (a) Clostridium sp001916075, (b) Blautia A obeum, and (c) Clostridium sp900540255 with variants in the FUT2 gene locus (within a 300-kb window); (d) Coprobacillus cateniformis with variants in the MUC12 gene locus (within a 500-kb window); (e) Clostridium saudiense, and (f) Turicibacter sanguinis with variants in the CORO7-HMOX2 gene locus (within a 500-kb window); (g) Intestinibacter sp900540355 with variants in the FOXP1 gene locus (within a 1-Mb window); and (h) Agathobaculum butyriciproducens with variants in the SLC5A11 gene locus (within a 300-kb window). The lead variant is indicated as the purple diamond. Other SNPs are indicated by dots colored according to the linkage disequilibrium (r2) values with the lead variant calculated using SCAPIS dosages. P values in a, c, d, e, g, and h were calculated using logistic and in b and f using linear regression (two-sided tests). The horizontal dashed gray line indicates genome-wide significance threshold (−log10(5 × 10−8)).

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