Extended Data Fig. 8: Bidirectional Mendelian randomization of gut species and metabolic traits. | Nature Genetics

Extended Data Fig. 8: Bidirectional Mendelian randomization of gut species and metabolic traits.

From: Genome-wide association analyses highlight the role of the intestinal molecular environment in human gut microbiota variation

Extended Data Fig. 8

Forest plot showing results from bidirectional inverse variance weighted Mendelian randomization (MR) analyses (two-sided tests) of specific gut species (n = 16,017) with adiposity traits (n = 694,649) and LDL (n = 1.32 M). Data are presented as inverse variance weighted regression betas representing genetically proxied increase in either species abundance or trait, with estimates passing false discovery rate threshold (q < 0.05) depicted as filled circles and those with q ≥ 0.05 as empty circles. Gray lines show the 95% confidence intervals. Genetic variants P-threshold, variant inclusion threshold used to create the genetic instruments; LDL, low-density lipoprotein cholesterol; WHR, waist-hip ratio adjusted for body mass index (BMI).

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