Fig. 2: Manhattan plot for associations between genetic variants and 921 species in the discovery studies (n = 16,017).

The dashed black line represents the study-wide (P < 5.4 × 10−11, after Bonferroni correction of the genome-wide threshold), and the solid gray line genome-wide (P < 5.0 × 10−8) significant thresholds. Filled triangles represent binary outcomes (absence/presence), which were tested using logistic regression models; circles represent continuous outcomes (relative abundance), which were tested using linear regression models. All tests were two-sided. Loci not found previously in other GWAS at study-wide significance are indicated in purple.