Extended Data Fig. 1: Regional association plots of variants in the OR51E1-OR51E2, LCT, ABO, and FUT3-FUT6 gene loci. | Nature Genetics

Extended Data Fig. 1: Regional association plots of variants in the OR51E1-OR51E2, LCT, ABO, and FUT3-FUT6 gene loci.

From: Genome-wide association analyses highlight the role of the intestinal molecular environment in human gut microbiota variation

Extended Data Fig. 1

a-h, Regional association plots of (a) richness with variants in the OR51E1-OR51E2 gene locus (within a 100-kb window); (b) Negativibacillus sp000435195, (c) Phocea massiliensis, (d) Bifidobacterium adolescentis, and (e) Copromonas sp000435795 with variants in the LCT gene locus (within a 1-Mb window); (f) Mediterraneibacter torques, and (g) Faecalibacterium longum with variants in the ABO gene locus (within a 100-kb window); (h) Clostridium sp900540255 with variants in the FUT3-FUT6 gene locus (within a 100-kb window). The lead variant is indicated as the purple diamond. Other variants are indicated by dots colored according to the linkage disequilibrium (r2) values with the lead variant calculated using SCAPIS dosages. P values in a, c, d, e, and f were calculated using linear, and in b and h using logistic regression (two-sided tests). The horizontal dashed gray line indicates the genome-wide significance threshold (−log10(5 × 10−8)). For the ABO locus, the non-coding genes are also plotted (in gray).

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