Extended Data Fig. 7: GA signature overlaps. | Nature Genetics

Extended Data Fig. 7: GA signature overlaps.

From: High-content CRISPR activation screens identify synthetically lethal RNA-based mechanisms to sensitize cancer cells to targeted T cell cytotoxicity

Extended Data Fig. 7: GA signature overlaps.

(a) GA signatures stratified to their up- and down-regulated compartments (x axis, denoted as GA sub-signatures) and the log-transformed number of genes (y axis) that are differentially expressed only in monoculture (grey), only in coculture (black), or in both (cyan) conditions. (b) Overlap between pairs of GA sub-signatures (quantified as log10-transformed one-sided hypergeometric p-value, without correction for multiple hypothesis testing, bottom right color bar) shown as a clustered heatmap. The sub-signatures assignment to clusters is noted (C1-C5). The up- and down-regulated sub-signatures of sensitizing and resistance hits, respectively, are annotated as having a “sensitizing” effect. The up- and down-regulated sub-signatures of resistance and sensitizing hits, respectively, are annotated as having a “resistance” effect.

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