Fig. 3: Genetic association of T1D at the MHC locus.
From: Genetic association and machine learning improve the prediction of type 1 diabetes risk
a, T1D association analysis of variants at the MHC locus using two-sided Firth bias-corrected LogReg. P values are from the marginal T1D association statistics from meta-analysis of n = 29,746 (T1D, n = 10,107; nondiabetic, n = 19,639) individuals. The lead variant for each signal is colored blue and signals with P < 1 × 10−325 were capped at this threshold for display. The gene map shows the location of class I and II HLA genes. b, The number of variants per credible set is shown for the 23 signals identified in conditional fine-mapping. c, Locus plots showing variant P values for conditional association signals at the MHC locus from two-sided Firth bias-corrected LogReg of n = 29,746 individuals. Locus plots are colored by linkage (r2) to the lead variant for each signal. HLA-DQB1:A57 refers to variants in HLA-DQB1 at position 57 and HLA-DRB1:FH13 refers to variants in HLA-DRB1 at amino acid position 13. The gene maps show the locations of class I and II HLA genes. CS, credible set.
