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The Single Cell Notebooks for inclusive and accessible training in single-cell and spatial omics

The Single Cell Notebooks provide multilingual, open-access training materials for single-cell and spatial transcriptomics analysis through reusable notebooks. They have evolved into a community-driven platform for education and capacity building, lowering language and computational barriers to support equitable participation in omics research.

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Fig. 1: Global reach and geographic distribution of scNotebooks training programs.
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References

  1. Picelli, S. RNA Biol. 14, 637–650 (2017).

    Article  PubMed  Google Scholar 

  2. Maracaja-Coutinho, V. & Severino, P. in Transcriptomics in Health and Disease (ed. Passos, G. A.) 127–141 (Springer, 2022).

  3. Wang, S. et al. Int. J. Mol. Sci. 24, 2943 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Atta, L. & Fan, J. Nat. Commun. 12, 5283 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Lähnemann, D. et al. Genome Biol. 21, 31 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Liu, X. et al. J. Hematol. Oncol. 17, 72 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Possik, P. A. et al. Cell 188, 5790–5796 (2025).

    Article  CAS  PubMed  Google Scholar 

  8. Maracaja-Coutinho, V. & Nakaya, H. I. Nat. Rev. Mol. Cell Biol. 27, 1–3 (2026).

    Article  CAS  PubMed  Google Scholar 

  9. Didier, J. et al. Endocr. Relat. Cancer 32, e250024 (2025).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Hemberg, M. et al. Genome Biol. 26, 358 (2025).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Clough, E. et al. Nucleic Acids Res. 52, D138–D144 (2024).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. CZI Cell Science Program et al. Nucleic Acids Res. 53, D886–D900 (2025).

  13. George, N. et al. Nucleic Acids Res. 52, D107–D114 (2024).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Armingol, E., Baghdassarian, H. M. & Lewis, N. E. Nat. Rev. Genet. 25, 381–400 (2024).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

This work was supported by the Agencia Nacional de Investigación y Desarrollo (ANID, Chile): FONDECYT (1211731 to V.M.C. and 3250452 to D.P.S.), FONDAP (15130011 and 1523A0008 to V.M.C.), Anillo (ATE220016 to V.M.C.) and BECAS CHILE (2018–72190270 to E.A.); by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, Brazil), through the PrInt program (to V.M.C.); by the Chan Zuckerberg Initiative (CZI, USA) (to A.M.E., J.R., P.S., M.B., Y.C.A., B.S.C. and V.M.C.); by the Gates Foundation (to A.K.S.); by the European Union through a Marie Skłodowska-Curie Actions Postdoctoral Fellowship (grant agreement no. 101208051 to E.A.); and by Pew Latin American Fellowship Program in Biomedical Sciences (to S.T.). We are also grateful to the Wellcome Connecting Sciences for the continuous support in several practical workshops and symposiums organized over the years in the region.

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Correspondence to Vinicius Maracaja-Coutinho.

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Rojas-Hidalgo, A., Arias-Carrasco, R., Silva, J.K. et al. The Single Cell Notebooks for inclusive and accessible training in single-cell and spatial omics. Nat Genet (2026). https://doi.org/10.1038/s41588-026-02584-0

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