We developed a genome-wide allele-specific methylation framework using long-read sequencing to characterize intergenerational epigenetic inheritance in mice. This framework revealed non-Mendelian inheritance, including emergent epialleles, imprinting events and paramutation, in a non-transgenic mammalian genome.
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References
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This is a summary of: Davidovich, A. et al. Non-Mendelian inheritance of DNA methylation patterns in mice. Nat. Genet. https://doi.org/10.1038/s41588-026-02604-z (2026).
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Allele-specific methylation uncovers non-Mendelian inheritance. Nat Genet (2026). https://doi.org/10.1038/s41588-026-02603-0
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DOI: https://doi.org/10.1038/s41588-026-02603-0
