Fig. 5: Dominant trans-acting meQTLs, transvection and paramutation.
From: Non-Mendelian inheritance of DNA methylation patterns in mice
a, Generic representation of methylation in the context of a dominant trans-acting meQTL, transvection or paramutation in inbred CC019 and CC037 samples and their F1 crosses. b, Dominant trans-acting meQTL/transvection/paramutation methylation pattern identified in both the liver (left) and muscle (right) over Vps37c. c, Paramutation methylation pattern identified in the liver over Capn11, shown for inbred and F1 samples (left) and F2 samples (right). d, Generic representation of methylation in the context of paramutation driven by the presence of a strain-specific IAP element in the inbred (left), F1 (middle) and F2 (right) generations. e, Methylation over the CC037-specific Vps37c IAP is shown for the inbred and F1 samples of the liver (left), inbred and F1 samples of the muscle (center), and F2 samples of the liver (left). For the liver F2s, only those samples/alleles with an average coverage of at least 1× over the region shown are included. The IAP is highlighted in blue and the original DMR (identified without inclusion of the IAP in the reference genome) is highlighted in red. As these plots no longer conform to the original pseudohybrid intermediate coordinate system due to the addition of the IAP, a single anchor coordinate indicating the start of the IAP is shown. f, Methylation over the CC037-specific Capn11 IAP shown for the inbred and F1 samples of the liver (left), inbred and F1 samples of muscle (center), and F2 samples of the liver (left). The IAP is highlighted in blue. g, Total expression of Drap1 in the liver, exhibiting a dominant trans-acting eQTL/transvection/paramutation expression pattern and proximal to a dominant trans-acting meQTL/transvection/paramutation methylation pattern in the liver. Expression was analyzed in 6 CC019 inbred, 9 CC037 inbred and 14 F1 mice. For the methylation plots shown in b, c, e and f, bold lines represent coverage-weighted mean methylation of the respective groups and CpG sites included in the final analysis are denoted by tick marks on the x axis.
