Supplementary Figure 5: WT and DKO ABCs exhibit distinct transcriptional and chromatin profiles
From: Regulation of age-associated B cells by IRF5 in systemic autoimmunity
(a) Expression of selected transcription factors in WT and DKO ABC cells as identified by RNA-seq analysis. (n = 2 mice/group). (b) Genomic distribution of WT ABC-specific and DKO ABC-specific peaks of ATAC-seq relative to annotated genomic features. (n = 2 mice/group) (c) Normalized ATAC-seq tag distributions tracks for representative genomic regions at Maf, Mafb and Znhit1 genes. Highlighted are WT ABC or DKO ABC-specific ATAC-seq peaks (n = 2 mice/group).
