Supplementary Figure 3: Sequence alignment of the different human CD1 isoforms
From: T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids
Residues on the CD1c α-helices that interacted with the 3C8 TCR are highlighted. Alanine-substituted residues are highlighted to indicate effects on CD69 expression by J76.3C8 cells: > 50% decrease, red; < 25% decrease, green. Residues that were not substituted are colored purple. * identical residue; : conserved residue;. conserved residue in 3 CD1 isoforms.
