Supplementary Figure 3: Change of ‘viral’ and ‘bacterial’ molecular scores over time and association with influenza viral load. | Nature Immunology

Supplementary Figure 3: Change of ‘viral’ and ‘bacterial’ molecular scores over time and association with influenza viral load.

From: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza

Supplementary Figure 3: Change of ‘viral’ and ‘bacterial’ molecular scores over time and association with influenza viral load.

(a) ‘Viral’ molecular scores plotted for 59 influenza patients (2010/11 cohort) who provided T1 and T2 samples, plotted against respective day of illness at time of sampling. (b) Change in ‘viral’ molecular score between first (T1) and precise second time point (48 hours after T1) in 41 patients with appropriate samples available (P= 0.0002, Mann-Whitney test, two-tailed). (c) ‘Bacterial’ molecular score plotted for 59 influenza patients who had both a T1 and a T2 sample, shown plotted against respective day of illness. (d) Change in ‘bacterial’ molecular score between T1 and precise T2 (48h post T1), in 41 patients with appropriate samples available (NS, Mann-Whitney test, two-tailed). (e) Influenza viral load estimation (pfu/ml) in nasopharyngeal samples obtained at T1 (n=42) and T2 (n=40). Bars show the median and interquartile range. Zero values were reassigned a value of 0.001 for display purposes. Mann Whitney test (two-tailed); ** P=0.0094. (f) Relationship between influenza viral load (pfu/ml) at T1 or T2 and the simultaneous ‘viral’ molecular score on whole blood (n=82).

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