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Tuberculous meningitis: a roadmap for advancing basic and translational research

Nature Immunology volume 19, pages 521–525 (2018)Cite this article

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Tuberculous meningitis is a serious, life-threatening disease affecting vulnerable populations, including HIV-infected individuals and young children. The US National Institutes of Health convened a workshop to identify knowledge gaps in the molecular and immunopathogenic mechanisms of tuberculous meningitis and to develop a roadmap for basic and translational research that could guide clinical studies.

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Fig. 1: Knowledge gaps in molecular mechanisms and immunopathogenesis.
Fig. 2: Advancing preclinical and translational research.
Fig. 3: Paradoxical reaction in a young child with TBM.

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Author information

Authors and Affiliations

  1. Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Sanjay K. Jain, Elizabeth W. Tucker & Alvaro A. Ordonez

  2. Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Sanjay K. Jain, Elizabeth W. Tucker & Alvaro A. Ordonez

  3. Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Sanjay K. Jain & Alvaro A. Ordonez

  4. Departments of Molecular Genetics and Microbiology and of Immunology, Duke University School of Medicine, Durham, NC, USA

    David M. Tobin

  5. Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Elizabeth W. Tucker

  6. Department of Basic Medical Sciences, Western University of Health Sciences, Pomona, CA, USA

    Vishwanath Venketaraman

  7. Columbus Technologies, Inc., Contractor to the National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, MD, USA

    Lakshmi Jayashankar

  8. Global Neurology Program, Division of Neuro-Immunology, Center for Virology and Vaccine Research, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    Omar K. Siddiqi

  9. Department of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia

    Omar K. Siddiqi

  10. Center for Infectious Disease Imaging, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA

    Dima A. Hammoud

  11. Sabin Research Institute, Children’s Hospital Los Angeles, Los Angeles, CA, USA

    Nemani V. Prasadarao

  12. Department of Pathology and Laboratory Medicine, University of Wisconsin–Madison School of Medicine and Public Health, Madison, WI, USA

    Matyas Sandor & Zsuzsanna Fabry

  13. Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA

    Richard Hafner

Authors
  1. Sanjay K. Jain
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  2. David M. Tobin
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  3. Elizabeth W. Tucker
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  4. Vishwanath Venketaraman
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  5. Alvaro A. Ordonez
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  6. Lakshmi Jayashankar
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  7. Omar K. Siddiqi
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  8. Dima A. Hammoud
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  9. Nemani V. Prasadarao
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  10. Matyas Sandor
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  12. Zsuzsanna Fabry
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on behalf of the NIH Tuberculous Meningitis Writing Group

Corresponding authors

Correspondence to Sanjay K. Jain or Zsuzsanna Fabry.

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The authors declare no competing interests.

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Jain, S.K., Tobin, D.M., Tucker, E.W. et al. Tuberculous meningitis: a roadmap for advancing basic and translational research. Nat Immunol 19, 521–525 (2018). https://doi.org/10.1038/s41590-018-0119-x

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