Supplementary Figure 3: Baseline molecular components are differentially associated with cytokine responses to pathogens.
From: Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses
Spearman correlations between stimulated cytokine production (after correction for age- and gender-effects) and the top 5 (when taking effect size into account) most-selected metabolites (total cholesterol level in HDL3, glutamine, free cholesterol and α-1 acid glycoprotein) and mediators (α-1 antitrepsin, IL-18BP, adiponecting, resistin and leptin) show differential effects between monocyte- and lymphocyte-derived cytokine measurements as well as across multiple stimulations. Sample size was n = 377 for the metabolites and n = 489 for the modulators, with each sample representing an individual.
