Supplementary Figure 5: Correlations between stimulated cytokine production and polygenic risk scores for immune disease.
From: Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses
(a) Spearman correlations between PRS and stimulated cytokine production remain largely stable across multiple GWAS thresholds. Spearman correlations between PRS and cytokine measurements (n = 430) show similar direction and effect size across the multiple GWAS thresholds (indicated by the color of the boxplot) used for calculating PRS for most immune diseases tested. (b) Distribution of permuted mean correlations between disease risk in monocyte derived cytokines (left panel) and lymphocyte derived cytokines (right panel) shows the measured mean estimate (red arrow) differs from the permuted distribution for all diseases showing significant changes.
