Supplementary Figure 4: 4C analysis of chromatin contacts. | Nature Immunology

Supplementary Figure 4: 4C analysis of chromatin contacts.

From: Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation

Supplementary Figure 4: 4C analysis of chromatin contacts.

a) Top: Chromosomal coordinates, genes, inducible genes, enhancers22, super-enhancers (SEs), CTCF ChIP-seq and TADs. Below: Main trend at 5kb resolution (mean with 20th to 80th percentile and normalized values in sliding windows sized 2-50kb (colors). Chromatin interactions in wild-type macrophages before and 2 h after LPS, suggesting re-configured interactions of the Egr2 promoter with the downstream super-enhancer. Two merged biological replicates. b) Interactions of the Egr2 promoter with downstream super-enhancer in wild-type and Rad21-/- macrophages before and after LPS (2 h). Two merged biological replicates. c) Interactions of the Egr2, Ifnar1, and Cebpb promoters before and 8 h after TEV induction in RAD-TEV macrophages.

Back to article page