Supplementary Figure 5: Motif analysis of Bcl11b-dependent co-factor peaks.
From: Bcl11b sets pro-T cell fate by site-specific cofactor recruitment and by repressing Id2 and Zbtb16
(a), Top three enriched sequence motifs of Bcl11b peaks in DN3 cells (Fig. 3b) are shown. (b), Top three enriched sequence motifs of Bcl11b-dependent co-factor peaks in DN3 cells (Fig.3c) are shown. (c), Top three enriched sequence motifs of new co-factor peaks in Bcl11b-deficient cells (Fig. 3c, 4) are shown. Note that most of these new peaks do not coincide with sites that Bcl11b normally occupies in wildtype cells: see Mta2, Rest, LSD1 and Runx1 Venn diagrams in Fig. 3c. (d), Venn diagrams show the numbers of ChIP peaks in each category overlapping with Bcl11b peaks at CpG islands. Data are based on reproducible ChIP-seq peaks in two independent replicate samples.
