Supplementary Figure 8: Increased fraction of progenitor exhausted CD8+ T cells is associated with duration of response to checkpoint blockade in patients with advanced melanoma. | Nature Immunology

Supplementary Figure 8: Increased fraction of progenitor exhausted CD8+ T cells is associated with duration of response to checkpoint blockade in patients with advanced melanoma.

From: Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

Supplementary Figure 8: Increased fraction of progenitor exhausted CD8+ T cells is associated with duration of response to checkpoint blockade in patients with advanced melanoma.The alternative text for this image may have been generated using AI.

a, Diagram of the functions of progenitor exhausted and terminally exhausted CD8+ T cells in the tumor microenvironment. b, Swimmer plots of 25 patients with advanced melanoma who received nivolumab (anti-PD-1) and ipilimumab (anti-CTLA-4) showing progression-free survival and overall survival. c, Frequency of progenitor exhausted cells in all activated/exhausted cells plotted against progression-free survival (days) in patients without durable clinical benefit (non-responders, n = 11). Linear regression line shown. d, Graph plotting the significance value from survival analysis for different cutoff ratios of TCF1+ in PD-1+CD8+ T cells (black line) or CD8+ T cells in all nucleated cells (gray line), from 0 to max ratio in responders (n = 14). Dotted line at p = 0.05. e,f, Kaplan-Meier curves of overall survival in responders (n = 14) by high vs. low percentage of total CD8+ T cells in all nucleated cells (e, cutoff at median 7.6%) or by percentage of progenitor exhausted cells (TCF1+) in all activated/exhausted CD8+ T cells (f, cutoff at median 14.9%). two-sided Likelihood ratio test (d-f); n.s. p > 0.05.

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