Supplementary Figure 7: Recall CD8+ T cell responses in HHD-A2 mice.
From: Human CD8+ T cell cross-reactivity across influenza A, B and C viruses
(a) Experimental outline for secondary infection with IBV. (b) Gating strategy. (c) Number of IFN-γ/TNF-producing CD8+ T cells specific for A2/BHA543 during 1o and 2o IBV infections (n = 5 mice for 1o and n = 4 for 2o). Mean and SEM are shown. (d) Polyfunctionality of BHA543 and BNS1266 during 1o and 2o IBV infections. % of triple (IFN-γ+IL-2+TNF+) CD8+ T cells of the two specificities during 1o and 2o IBV infections (n = 5 mice for 1o and n = 4 for 2o). Mean and SEM are shown. Statistical significance was determine using an unpaired two-tailed t-test, *p < 0.05, **p < 0.005.
