Supplementary Figure 7 | Nature Immunology

Supplementary Figure 7

From: Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity

Supplementary Figure 7

Microarray analysis of primary islets reveals a unique signature of a highly proliferative β cell population. a, GSEA analyses of the pathways affected by Tlr2-Tlr4 deficiency in primary islets of mice on 7-month HFD, with top up-regulated pathways shown. b,d, Heat map showing top upregulated genes (greater than 2.0 fold, p < 0.01) in Tlr2−/−Tlr4−/− compared to B6 islets from mice on a HFD for 7 months (b) or 5 weeks (d). n = =4, 4 mice (7-month), n = 2, 4 (5 weeks). p value, by IBMT regularized t test. c, Pie chart analysis of microarray data showing 45 and 101 up-regulated genes in Tlr2−/−Tlr4−/− vs. B6 islets from 5-week and 7-month-HFD mice, respectively.

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