Supplementary Figure 6: IFN-λ signaling in DCs is required for optimal DC function and generation of CD8+ T cell responses capable of mediating protection against heterosubtypic IAV re-challenge. | Nature Immunology

Supplementary Figure 6: IFN-λ signaling in DCs is required for optimal DC function and generation of CD8+ T cell responses capable of mediating protection against heterosubtypic IAV re-challenge.

From: Interferon-λ modulates dendritic cells to facilitate T cell immunity during infection with influenza A virus

Supplementary Figure 6: IFN-λ signaling in DCs is required for optimal DC function and generation of CD8+ T cell responses capable of mediating protection against heterosubtypic IAV re-challenge.The alternative text for this image may have been generated using AI.

Following IAV infection, DCs become activated and migrate to initiate IAV-specific CD8+ T cell responses capable of mediating protection against heterosubtypic IAV re-challenge. In Ifnlr1−/−, DC migration and activation are aberrant, and DCs produce IL-10, which correlates with a reduced IAV-specific CD8+ T cell responses that is unable to protect against heterosubtypic IAV re-challenge.

Back to article page