Supplementary Figure 1: IFN-λ signaling contributes to controlling viral load, but not disease severity, during primary IAV infection. WT and Ifnlr1−/− mice were mock- or IAV-infected with 40 PFU of the mouse-adapted H1N1 strain A/PR/8/34 (PR8) | Nature Immunology

Supplementary Figure 1: IFN-λ signaling contributes to controlling viral load, but not disease severity, during primary IAV infection. WT and Ifnlr1−/− mice were mock- or IAV-infected with 40 PFU of the mouse-adapted H1N1 strain A/PR/8/34 (PR8)

From: Interferon-λ modulates dendritic cells to facilitate T cell immunity during infection with influenza A virus

Supplementary Figure 1: IFN-λ signaling contributes to controlling viral load, but not disease severity, during primary IAV infection. WT and Ifnlr1−/− mice were mock- or IAV-infected with 40 PFU of the mouse-adapted H1N1 strain A/PR/8/34 (PR8)The alternative text for this image may have been generated using AI.

. a. On days 1, 3, 5, 7, and 9 p.i., lungs were harvested, homogenized, and pulmonary virus titer was determined by plaque assay. Each point represents an individual animal, and data from two, pooled independent experiments are shown. Bars shown mean ± SEM. Day 0 n = 4/group, Day 1 n = 6/group, Day 3 n = 7/group, Day 5 n = 6/group, Day 7 n = 7 (WT) or 6 (Ifnlr1−/−)/group, Day 9 n = 12/group. Significance was determined using one-way ANOVA followed by Tukey’s multiple comparisons test. *indicates p<0.05 b & c. Weight loss (b) and illness score (c) was monitored over 12 days. Dashed line at illness score of 4 indicates presence of respiratory symptoms. n=2 (mock), 7 (WT IAV), or 6 (Ifnlr1−/− IAV) Symbols show mean and error bars represent SD.

Back to article page