Supplementary Figure 6: TREM1 is induced in the intestinal inflammatory Mo/MΦ subset after MCAo.
From: Peripheral TREM1 responses to brain and intestinal immunogens amplify stroke severity
ß-adrenergic inhibition with propranolol (ppl) has no effect on neutrophil TREM1 expression after MCAo. TREM1 MFI in neutrophils in sham, MCAo, and MCAo treated with propranolol (n=5 sham, n=8 MCAo and n=9 MCAo+ppl mice, mean +/- SEM). Percent change in volume of IL hemisphere in sham and MCAo mice +/- ppl 4.5h after MCAo (n=5 sham, n=9 MCAo and n=9 MCAo+ppl, mean +/- SEM). Immune factor changes at 4.5h in small intestine lamina propria (n=3–6 biologically independent samples per group, mean +/- SEM.; ** P <0.01 Student’s two tailed t-test). Quantification of bacterial colonies that grew out of blood collected from Trem1+/+ and Trem1-/- mice at 4.5h after MCAo (n=3 sham Trem1+/+, n=6 MCAo Trem1+/+ and n=4 MCAo Trem1-/- mice, mean +/- SEM).
