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CD8+ T CELLS

Tick-TOX, it’s time for T cell exhaustion

Nature Immunology volume 20, pages 1092–1094 (2019)Cite this article

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The transcription factor TOX epigenetically reprograms CD8+ T cells to drive T cell exhaustion during chronic infection and cancer. Although they are necessary for T cell persistence, these changes contribute to diminished anti-tumor function in exhausted cells.

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Fig. 1: TOX promotes differentiation to an exhausted state in CD8+ T cells.

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Authors and Affiliations

  1. NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA

    Thomas H. Mann & Susan M. Kaech

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  1. Thomas H. Mann
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  2. Susan M. Kaech
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Correspondence to Susan M. Kaech.

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Mann, T.H., Kaech, S.M. Tick-TOX, it’s time for T cell exhaustion. Nat Immunol 20, 1092–1094 (2019). https://doi.org/10.1038/s41590-019-0478-y

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