Supplementary Figure 3: Environmental sensing in T cells.
From: Quantitative analysis of T cell proteomes and environmental sensors during T cell differentiation
(a) The impact of immune activation on the lysosomal arginine sensor SLC38A9, the cytosolic arginine sensor CASTOR1, the leucine sensor SESTRIN2 and the mTORC1 activating GTPase RHEB. Histogram bars represent the mean +/- SD. (b) Copy numbers for GATOR complex members in naïve (N), TCR activated (T) and effector (E) CD8+ populations. Copy numbers are the average of replicates. For a and b, n = 6 biologically independent samples for CD8+ naïve cells and 3 biologically independent samples for each of the other T cell populations.
