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Endothelial cells instruct macrophages on how to Rspond to lung injury

Nature Immunology volume 21, pages 1317–1318 (2020) Cite this article

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The lung endothelial cell–derived angiocrine Rspondin3 activates Wnt–β-catenin signaling in interstitial macrophages, leading to a metabolic–epigenetic reprogramming of interstitial macrophages that drives anti-inflammatory responses and attenuates endotoxin-induced lung injury.

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Fig. 1: A new angiocrine–macrophage axis negatively regulates lung inflammatory injury in endotoxemic mice.
The alternative text for this image may have been generated using AI.

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Authors and Affiliations

  1. Laboratory of Immunophysiology, GIGA Institute, Liège University, Liege, Belgium

    Thomas Marichal

  2. Faculty of Veterinary Medicine, Liège University, Liege, Belgium

    Thomas Marichal

  3. WELBIO, Walloon Excellence in Life Sciences and Biotechnology, Wallonia, Belgium

    Thomas Marichal

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  1. Thomas Marichal
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Correspondence to Thomas Marichal.

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The author declares no competing interests.

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Marichal, T. Endothelial cells instruct macrophages on how to Rspond to lung injury. Nat Immunol 21, 1317–1318 (2020). https://doi.org/10.1038/s41590-020-00806-z

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