Fig. 6: EF response intensity is correlated with inflammatory biomarkers and high neutralizing antibody titers.

a, CXCL10 (IP-10) plasma concentration in HD (n = 13), CoV-A (n = 8) or CoV-B (n = 5) cohort. The asterisk denotes the highest value exceeding the testing range and was identified to be a statistical outlier (P < 0.00001). P-value reporting in parentheses indicates testing with outlier removed. b, IL-6 plasma concentration of HD (n = 13), CoV-A (n = 8) or CoV-B (n = 5) cohort. c, CRP concentration in the plasma of HD (n = 13), CoV-A (n = 8) or CoV-B (n = 5) cohort. d, Linear regression of CRP values as a function of IP-10 plasma levels (with outlier removed). e, Linear regression of CRP values as a function of IL-6 plasma levels. f, Linear regression of log(CRP) values as a function of DN2 B cell frequency of total DN B cells. g, RBD-specific responses grouped by indicated isotype in HD (n = 13), ICU-C (n = 10) or OUT-C (n = 7) cohort. h, RBD-specific responses as a function of time in HD, ICU-C or OUT-C cohort. Solid lines represent quadratic regression; shaded areas denote 95% confidence intervals of quadratic regression. i, Regression analyses of in vitro viral neutralization as a function of patient serum dilution in HD (n = 3), CoV-A (n = 4) or CoV-B (n = 3) clusters. Dagger indicates patient analyzed by single-cell V(D)J analysis (Fig. 5a–g). a–c,g, Statistical significance was determined using ANOVA with Tukey’s multiple-comparisons testing between groups. a–g, *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001; ****P ≤ 0.0001. Summary statistics: median (a–c); mean ± s.d. (g).