Extended Data Fig. 9: Phenotypic characteristics of TML/HCV cells targeting conserved versus variant epitopes. | Nature Immunology

Extended Data Fig. 9: Phenotypic characteristics of TML/HCV cells targeting conserved versus variant epitopes.

From: Memory-like HCV-specific CD8+ T cells retain a molecular scar after cure of chronic HCV infection

Extended Data Fig. 9: Phenotypic characteristics of TML/HCV cells targeting conserved versus variant epitopes.The alternative text for this image may have been generated using AI.

Flow cytometric analysis including various T cell memory and exhaustion/effector markers of TML/HCV cells in rHCV (n = 5), cHCV and cured HCV targeting either conserved epitopes (AG; cHCV: n = 12, cured HCV: n = 7) or variant epitopes (ESC; cHCV: n = 8, cured HCV: n = 6). t-SNE representation with scaled expression depicted as color code (red: high; blue: low) a, representative dot plots (including control analyses of non-naïve and naïve bulk CD8+ T cells) and bar charts (b; median fluorescence intensity (MFI) normalized to naïve CD8+ T cells) are depicted. Bar charts show the median with IQR. Significance was assessed by Kruskal-Wallis test (one-sided) including Dunn’s multiple comparisons test.

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