Extended Data Fig. 4: RORα binds to circadian rhythm associated genes in ILC2.
From: RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus
(a) Representative ATAC-seq tracks for thymic ETP, DN2, DN3, NKp and ILC2p, and binding profiles of RORα-T2A and GATA-3-T2A in ILC2 purified from lymph nodes of Rorateal/teal, Gata3hCD2TR/+ or wild type mice, and expanded in vitro with IL-7 and IL-33, around the Arntl and Clock loci. Tracks shown are representative of three independent experiments. (b) Representative ATAC-seq tracks for thymic ETP, DN2, DN3, NKp and ILC2p, and binding profiles of RORα-T2A and GATA-3-T2A in ILC2 (as in Fig. S4a) around the Il1rl1, Il2ra and Rora loci.
