Extended Data Fig. 5: Combined inhibition of mitochondrial and peroxisomal FAO with increased in vivo dosage of etomoxir and thioridazine in support of Fig. 5. | Nature Immunology

Extended Data Fig. 5: Combined inhibition of mitochondrial and peroxisomal FAO with increased in vivo dosage of etomoxir and thioridazine in support of Fig. 5.

From: Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis

Extended Data Fig. 5

Absolute number of live splenic NP+ GCBC (a) and naïve NP- B cells (b) and MFI of 2-NBDG of GCBC after 30 min 2-NBDG in vitro pulse (c) of mice at d14 post NP-CGG immunization and in vivo treatment at d9, d11 and d13 with 22 mg/kg etomoxir and 11 mg/kg thioridazine or vehicle only as in Fig. 5c–e. Every dot represents and individual mouse and graphs are mean + /-SEM; ns = not significant; ****p < 0.0001 by unpaired, two-tailed t-test.

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