Extended Data Fig. 3: Gpx4 knockdown specifically inhibits cGAS–STING signaling.
From: Redox homeostasis maintained by GPX4 facilitates STING activation
a, Protein levels of GPX4 in PMs transfected with Control siRNA (siCtrl) or GPX4 siRNAs (siGPX4-1, 2 or 3) for 48 h. b-e, IFN-β expression (b-d) and phosphorylated IRF3 level (e) in PMs transfected with siCtrl or siGPX4, followed by stimulation as indicated. Statistical significance was determined by unpaired two-sided multiple Student’s t-tests in b, c, d. Data are shown as mean ± SD or typical photographs of one representative from three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001.
