Extended Data Fig. 6: GPX4 has no effect on cGAS activity.
From: Redox homeostasis maintained by GPX4 facilitates STING activation
a,b, ChIP analysis of HSV-1 genomic DNA binding to cGAS in PMs from WT or Gpx4CKO mice (a) or PMs treated with DMSO or RSL3 (0.5 µM) (b). c, ELISA analysis of cGAMP production in PMs treated with DMSO or RSL3 (0.5 µM), followed by HSV-1 infection or ISD transfection. d, cGAMP activity was analyzed in PMs treated with DMSO or RSL3 (0.5 µM), followed by HSV-1 infection. e, cGAMP activity was analyzed in PMs from WT or Gpx4CKO mice, followed by HSV-1 infection. Statistical significance was determined by unpaired two-sided multiple Student’s t-tests in a-e. Data are shown as mean ± SD.
