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GERMINAL CENTER REACTIONS

Metabolic constraints on the B cell response to malaria

Early plasmablasts responding to Plasmodium infection may outcompete germinal center B cells for l-glutamine and delay pathogen control.

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Fig. 1: Model of the influence of l-glutamine and plasmablasts on the GC response to Plasmodium infection.

Gretchen Harms Pritchard

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Acknowledgements

We thank Gretchen Harms Pritchard for valuable discussions and figure design and Biorender figure graphics.

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Correspondence to Marion Pepper.

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Rodda, L.B., Pepper, M. Metabolic constraints on the B cell response to malaria. Nat Immunol 21, 722–724 (2020). https://doi.org/10.1038/s41590-020-0718-1

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