Extended Data Fig. 3: Individuals’ UMAP for Monocytes and B cells subclusters.
From: Mapping systemic lupus erythematosus heterogeneity at the single-cell level
a, Individual UMAP plots from 11 cHD (left), 33 cSLE (right) based on monocyte SCs (Mono-SCs, n = 8). Each color represents a distinct SC. b, Flow cytometry detection of ISG15 in PBMCs gated on CD14 + monocytes from 17 cSLE patients with different SLEDAI scores, as well as 14 cHD. c, Percentage of ISG15 + CD14 + monocytes in cHD and cSLE as categorized based on SLEDAI (cHD cells ‘none’ in gray, SLEDAI < = 4, in yellow; n = 9, and SLEDAI > 4, in red; n = 8). T-test was used for statistical analysis. P-values are shown for the respective comparisons. d, Individual UMAP plots from 11 cHD (left), 33 cSLE (right) based on B cells SCs (B-SCs, n = 7). Each color represents a distinct SC.
