Durable responses to immunotherapy require the development of robust CD8+ T cell memory. A new study indicates that NRP1 differs from other checkpoint receptors as it functions as a checkpoint for the generation of memory.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Neuropilin-1-target self-assembled peptide nanoparticles contribute to tumor treatment by inducing pyroptosis
BMC Cancer Open Access 06 March 2025
-
SARS-CoV-2-associated lymphopenia: possible mechanisms and the role of CD147
Cell Communication and Signaling Open Access 04 July 2024
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$32.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Liu, C. et al. Nat. Immunol. https://doi.org/10.1038/s41590-020-0733-2 (2020).
Overacre-Delgoffe, A. E. et al. Cell 169, 1130–1141.e11 (2017).
Leclerc, M. et al. Nat. Commun. 10, 3345 (2019).
Wherry, E. J. Nat Immunol 12, 492–499 (2011).
Hwang, J. Y., Sun, Y., Carroll, C. R. & Usherwood, E. J. Msphere 4, e00221–19 (2019).
Im, S. J. et al. Nature 537, 417–421 (2016).
Sade-Feldman, M. et al. Cell 175, 998–1013.e20 (2018).
Siddiqui, I. et al. Immunity 50, 195–211.e10 (2019).
Kurtulus, S. et al. Immunity 50, 181–194.e6 (2019).
Miller, B. C. et al. Nat. Immunol. 20, 326–336 (2019).
Utzschneider, D. T. et al. Immunity 45, 415–427 (2016).
Zhou, X. et al. Immunity 33, 229–240 (2010).
Yang, C. Y. et al. Nat Immunol 12, 1221–1229 (2011).
Lynn, R. C. et al. Nature 576, 293–300 (2019).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
A.C.A. is a member of the SAB for Tizona Therapeutics, Compass Therapeutics, Zumutor Biologics, ImmuneOncia and Astellas Global Pharma Development Inc., which have interests in cancer immunotherapy. A.C.A.’s interests were reviewed and managed by the Brigham and Women’s Hospital and Partners Healthcare in accordance with their conflict of interest policies.
Rights and permissions
About this article
Cite this article
Acharya, N., Anderson, A.C. NRP1 cripples immunological memory. Nat Immunol 21, 972–973 (2020). https://doi.org/10.1038/s41590-020-0759-5
Published:
Version of record:
Issue date:
DOI: https://doi.org/10.1038/s41590-020-0759-5
This article is cited by
-
Neuropilin-1-target self-assembled peptide nanoparticles contribute to tumor treatment by inducing pyroptosis
BMC Cancer (2025)
-
SARS-CoV-2-associated lymphopenia: possible mechanisms and the role of CD147
Cell Communication and Signaling (2024)
-
Imaging in Tumor Immunology
Nuclear Medicine and Molecular Imaging (2021)
