Fig. 2: Histopathological analysis of SARS-CoV-2 infection in K18-hACE2 mice. | Nature Immunology

Fig. 2: Histopathological analysis of SARS-CoV-2 infection in K18-hACE2 mice.

From: SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function

Fig. 2

a, Hematoxylin and eosin staining of lung sections from K18-hACE2 mice following mock infection or after intranasal infection with 2.5 × 104 p.f.u. SARS-CoV-2 at 2, 4 and 7 dpi. Images show low- (left; scale bars, 250 μm), medium- (middle; scale bars, 50 μm) and high-power magnification (right; scale bars, 25 μm). b, SARS-CoV-2 RNA in situ hybridization of lung sections from K18-hACE2 mice for the conditions described in a. Images show low- (left; scale bars, 100 μm), medium- (middle; scale bars, 100 μm) and high-power magnification (right; scale bars, 10 μm). In a and b, images are representative of n = 6 per group.

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