Extended Data Fig. 5: Distribution of cells states altered by TF ablation in Treg cells.
From: Functional CRISPR dissection of gene networks controlling human regulatory T cell identity
Cell density maps highlight the altered distribution of cell states assessed by scRNA-seq (visualized with t-SNE dimensionality reduction, Fig. 5a) in individual TF KO Treg cell conditions with and w/o IL-12 treatment. The colour scale represents the population densities of particular cell states across regions of the t-SNE map. Data were generated in ex vivo expanded Treg cells from 2 human blood donors, the same data referenced in Fig. 5. Detailed list of all conditions: Supplementary Table 3.
