Extended Data Fig. 10: A conceptual view for development of memory CD4+ T cells during malaria.
From: Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory
A broad overview of transcriptome dynamics accompanying transition of CD4+ T cells from naivety to memory. CD4+ T cells branch into effector TH1 and Tfh after undergoing clonal expansion, and exhibit partial retention of effector phenotypes as they transition to memory. TH1 effector cells give rise to Tr1 cells and TH1 phenotype TEM memory cells. Tfh effector cells give rise to TCM cells, GC Tfh cells, or memory Tfh cells. Genes correlating strongly with memory development are summarised in the box (right). Numbers in boxes denote the average number of genes detected by high-resolution scRNA-seq at different stages of CD4+ T cell differentiation.
