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IMMUNOREGULATION

IRGM1, a guardian of mitochondrial DAMP–mediated autoinflammation

Nature Immunology volume 22, pages 272–273 (2021)Cite this article

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IRGM1 is recognized as a master regulator of type I interferon responses against pathogens, while also protecting against autoimmune diseases. It has now been shown that IRGM1 controls autoinflammatory responses by modulating mitophagy flux.

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Fig. 1: IRGM1 controls mitochondrial DAMP signaling and IFN-I activation through distinct pathways in somatic and immune cells.

References

  1. Azzam, K. M. et al. JCI Insight 2, e91914 (2017).

    Article  Google Scholar 

  2. Tiwari, S., Choi, H.-P., Matsuzawa, T., Pypaert, M. & MacMicking, J. D. Nat. Immunol. 10, 907–917 (2009).

    Article  CAS  Google Scholar 

  3. Jena, K. K. et al. EMBO Rep. 21, e50051 (2020).

    Article  CAS  Google Scholar 

  4. Rodríguez-Nuevo, A. & Zorzano, A. Cell Stress 3, 195–207 (2019).

    Article  Google Scholar 

  5. Riley, J. S. & Tait, S. W. G. EMBO Rep. 21, e49799 (2020).

    Article  CAS  Google Scholar 

  6. Rai, P. et al. Nat. Immunol. https://doi.org/10.1038/s41590-020-00859-0 (2021).

  7. Hunn, J. P. & Howard, J. C. PLoS Pathog. 6, e1001008 (2010).

    Article  Google Scholar 

  8. Taylor, G. A. et al. PLoS Pathog. 16, e1008553 (2020).

    Article  CAS  Google Scholar 

  9. Springer, H. M., Schramm, M., Taylor, G. A. & Howard, J. C. J. Immunol. 191, 1765–1774 (2013).

    Article  CAS  Google Scholar 

  10. Mathur, A., Hayward, J. A. & Man, S. M. J. Leukoc. Biol. 103, 233–257 (2018).

    CAS  PubMed  Google Scholar 

  11. West, A. P. & Shadel, G. S. Nat. Rev. Immunol. 17, 363–375 (2017).

    Article  CAS  Google Scholar 

  12. Sliter, D. A. et al. Nature 561, 258–262 (2018).

    Article  CAS  Google Scholar 

  13. Li, H. et al. Oxid. Med. Cell. Longev. 2016, 1987149 (2016).

    PubMed  Google Scholar 

  14. Schmidt, E. A. et al. J. Biol. Chem. 292, 4651–4662 (2017).

    Article  CAS  Google Scholar 

  15. Henry, S. C., Schmidt, E. A., Fessler, M. B. & Taylor, G. A. PLoS ONE 9, e95021 (2014).

    Article  Google Scholar 

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Authors and Affiliations

  1. Center for Metabolism and Mitochondrial Medicine, Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Brett A. Kaufman

  2. Aging Institute, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Ana L. Mora

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  1. Brett A. Kaufman
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  2. Ana L. Mora
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Correspondence to Ana L. Mora.

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Kaufman, B.A., Mora, A.L. IRGM1, a guardian of mitochondrial DAMP–mediated autoinflammation. Nat Immunol 22, 272–273 (2021). https://doi.org/10.1038/s41590-021-00877-6

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