Extended Data Fig. 4: Riok2 haploinsufficient erythroid precursors express increased S100 proteins.
From: Blockade of IL-22 signaling reverses erythroid dysfunction in stress-induced anemias
(a) Expression of ribosomal proteins quantified by proteomics in Riok2f/+Vav1cre and Riok2+/+Vav1cre erythroid precursors. S100A8 (b) and S100A9 (c) expression assessed by flow cytometry in BM erythroid precursors from Riok2f/+Vav1cre and Riok2+/+Vav1cre mice. n = 4mice/group. d,e, S100a8 and S100a9 mRNA expression in erythroid precursors isolated from Riok2f/+Vav1cre and Riok2+/+Vav1cre mice. n = 4 mice/group. f, p53 expression assessed by flow cytometry in BM erythroid precursors from Riok2f/+Vav1cre and Riok2+/+Vav1cre mice. g, Graphical representation of data shown in (e). n = 5 mice/group. Data are shown as mean ± s.e.m and are representative of two (b to g) independent experiments. Unpaired two-tailed t-test (b to g) used to calculate statistical significance. ** p<0.01, *** p<0.001, **** p<0.0001.
