Extended Data Fig. 6: Neutralization of IL-22 signaling increases number of erythroid precursors.
From: Blockade of IL-22 signaling reverses erythroid dysfunction in stress-induced anemias
a-d, Number of RI-RIV erythroid populations among viable BM cells in the indicated strains undergoing PhZ-induced stress erythropoiesis. For (a), n = 5,5,4, and 4 for Riok2+/+Il22+/+Vav1cre, Riok2+/+Il22+/-Vav1cre, Riok2f/+Il22+/+Vav1cre, Riok2f/+Il22+/-Vav1cre, respectively. For (d), n = 5/group. Data are shown as mean ± s.e.m and are representative of three (a, c) or two (b, d) independent experiments. 1-way ANOVA with Tukey’s correction (a, c) or unpaired two-tailed t-test (b, d) used to calculate statistical significance. * p < 0.05, ** p < 0.01.
