Extended Data Fig. 9: Increased IL-22 and its signature genes in del(5q) MDS subjects.
From: Blockade of IL-22 signaling reverses erythroid dysfunction in stress-induced anemias
a, Representative flow cytometry plots showing frequency of CD4+IL-22+ cells among total PBMCs in the peripheral blood of MDS patients and healthy subjects. Pre-gated on viable CD3ε+CD4+ cells. Cumulative data shown in Fig. 4e. b, Expression of indicated IL-22 signature genes in CD34+ cells from healthy controls and del(5q) and non−del(5q) MDS patients. n = 17, 47, and 136 for healthy, del(5q) MDS, and non-del(5q) MDS, respectively. Kruskal-Wallis test with Dunn’s correction for multiple comparisons (b) used to calculate statistical significance * p<0.05, ** p<0.01, *** p<0.001, **** p<0.0001. Solid lines represent median and dashed lines represent quartiles (b).
