Fig. 5: Blocking TLR2 signaling protects against SARS-CoV-2 infection in vivo.
From: TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines
a, Levels of TNF-α, IFN-γ, IL-6, G-CSF, CXCL10 and MCP-1 in the BALF of mice 2 d after SARS-CoV-2 infection. b, Pooled survival of 8-to-10-week-old K18–hACE2 transgenic mice after infection with SARS-CoV-2 (2 × 104 p.f.u. per mouse). c, Pooled body weight change of infected mice in b. Significant differences compared with the group treated with oxPAPC are denoted as: *P < 0.05, **P < 0.01, and ***P < 0.001 (two-sided Student’s t-test (a), log-rank test (b) or two-way ANOVA (c)). Exact P values are presented in Supplementary Table 1. Data are shown as mean ± s.e.m. (n = 3–4 biological replicates (a) or n = 14–16 biological replicates (b and c)).
