Extended Data Fig. 4: oxPAPC is a potent TLR2 inhibitor.
From: TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines
a, Immunoblot analysis of phospho-ERK (pERK), total ERK (tERK), pIκB, and tIκB in WT and Tlr2–/– bone marrow-derived macrophages (BMDMs) after stimulation with 1 μg/ml of Pam3CSK4 (Pam3) for the indicated time with or without the TLR2 inhibitor oxPAPC or C29. b, Immunoblot analysis of pERK, tERK, pIκB, and tIκB in WT and Tlr7–/– BMDMs after stimulation with 1 μg/ml of R848 for the indicated time with or without the TLR2 inhibitor oxPAPC or C29. Data are representative of two independent experiments.
