Extended Data Fig. 9: Impact of healthy donors on microbiome analysis of integrated SARS-CoV-2 immune responses.
From: Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection
Multidimensional scaling (MDS) projection for (a) nasopharyngeal compartment (nasal cytokines, nasal antibodies, nasal virus neutralization, nasal viral load and nasal microbiome) and (c) systemic compartment (plasma cytokines, plasma antibodies, serum virus neutralization, blood viral load and nasal microbiome). The dotted lines represent the most associated measures. (b) and (d) show individual correlation plots between Genus abundance (%) and cytokines and specific antibodies. (b) and (d) Cytokines and viral load were measured in the plasma of healthy controls (n = 12 donors), mild to moderate (n = 15 patients), severe (n = 11 patients) and critical (n = 23 patients) or in the nasopharyngeal compartment of healthy controls (n = 10 donors), mild to moderate (n = 10 patients), severe (n = 10 patients) and critical (n = 12 patients). In (b) and (d), σ represents Spearman coefficient and p the p value. For all panels: *P < 0.05; **P < 0.01; ***P < 0.001.
