Table 1 Groups defined by shared TRBV gene usage and CDR3β sequence between bulk TCR sequencing from T cell clones and single-cell TCR sequencing from ex vivo T cells
Group | CDR3β | TRBV | TRBJ | Functional avidity |
|---|---|---|---|---|
1 | CAISEPGTSGGAILDTQYF | TRBV10-3 | TRBJ2-3 | Low |
2 | CASGPATSAEQETQYF | TRBV12-5 | TRBJ2-5 | High |
3 | CASSILQGLGGSNQPQHF | TRBV19 | TRBJ1-5 | Low |
4 | CASSVLPGPPRGEQFF | TRBV2 | TRBJ2-1 | High |
5 | CSAQVGGNYNSPLHF | TRBV20-1 | TRBJ1-6 | High |
6 | CATSDLVTSGDEQFF | TRBV24-1 | TRBJ2-1 | Low |
7 | CASSGLTSLADTQYF | TRBV25-1 | TRBJ2-3 | High |
8 | CASSLITGGAKNIQYF | TRBV27 | TRBJ2-4 | Low |
9 | CASSPIAGGRKNIQYF | TRBV27 | TRBJ2-4 | Low |
10 | CASSPLTGSAERKETQYF | TRBV27 | TRBJ2-5 | High |
11 | CASSPLVGERFRKETQYF | TRBV27 | TRBJ2-5 | Low |
12 | CASSSLLAGGFYEQFF | TRBV27 | TRBJ2-1 | Low |
13 | CASSPIETAKNIQYF | TRBV28 | TRBJ2-4 | Low |
14 | CASSSITTTGAKDGYTF | TRBV28 | TRBJ1-2 | High |
15 | CASSLAGAEAFF | TRBV5-1 | TRBJ1-1 | High |
16 | CASSLAGGPLHEQFF | TRBV5-1 | TRBJ2-1 | Low |
17 | CASSSYPGLAPVQETQYF | TRBV5-1 | TRBJ2-5 | High |
18 | CASSYLPAGSSYNSPLHF | TRBV6-3 | TRBJ1-6 | High |
