Extended Data Fig. 8: Intestinal epithelial cell responses in the absence of ILC3-specific HB-EGF.
a–d, Hbegff/f and Hbegf△ILC3 mice were challenged with 3% DSS for 6 days (n = 6 individual mice). The functional ability of intestinal epithelium was analyzed, including anti-microbial peptides production (a), tight junction proteins expression (b), stem cell composition (c) and proliferative ability (d) (N = 4 individual mice per group, n = 27 crypts quantified per group). e, Schematic model of chronic colitis induction. Data in a–d are representative of two independent experiments, shown as the means ± S.E.M. Statistics are calculated by unpaired two-tailed Student’s t-test. Scale bars=50 μm.
